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Unlike PURINETHOL (mercaptopurine) and IMURAN® (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. You will need to discuss the benefits and risks of using Allopurinol  while you are pregnant. {07} {35} {36} Both allopurinol and the uricosuric antigout agents are effective in patients whose 24-hour renal excretion of uric acid is 800 mg (4. A reaction with another antigout drug, allopurinol, may cause a rash. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}.

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